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Watanabe Nobuhiro

    Autonomic Neuroscience　Researcher
Last Updated :2025/02/15

Researcher Information

Degree

  • Ph.D.（2008/12 Royal Melbourne Institute of Technology (Australia)）

URL

Research funding number

  • 00540311

ORCID ID

J-Global ID

Research Interests

  • Autonomic Nervous System   Melatonin   Pineal gland   Skin sensory receptors   Pain   Skeletal muscle   Touch   Spinal cord   basal forebrain   in vivo imaging   Neurovascular coupling   Cerebral blood flow   

Research Areas

  • Life sciences / Physiology / Cardiovascular system
  • Life sciences / Rehabilitation science / Somatosensory stimulation
  • Life sciences / Neuroscience - general / Cerebral blood flow and metabolism
  • Life sciences / Animals: biochemistry, physiology, behavioral science / Autonomic Nervous System

Academic & Professional Experience

  • 2015/04 - Today  Tokyo Metropolitan Geriatric Hospital and Institute of GerontologyDepartment of Autonomic NeuroscienceResearcher (full-time, tenured)
  • 2010/04 - 2015/03  Tokyo Metropolitan Geriatric Hospital and Institute of GerontologyDepartment of Autonomic NeuroscienceResearcher (full-time)
  • 2009/04 - 2010/03  Tokyo Metropolitan Geriatric Hospital and Institute of GerontologyDepartment of Autonomic NeuroscienceResearcher (part-time)
  • 2008/07 - 2009/03  Royal Melbourne Institute of Technology (Australia)Lecturer (part-time)
  • 2008/05 - 2008/06  Royal Melbourne Institute of Technology (Australia)Research assistant

Education

  • 2006/02 - 2008/12  Royal Melbourne Institute of Technology  School of Health Sciences  Division of Chiropractic
  • 2004/02 - 2006/01  Royal Melbourne Institute of Technology  School of Health Sciences  Division of Chiropractic

Published Papers

Books etc

  • フレイル・ロコモのグランドデザイン
    堀田晴美; 渡邉信博 (Contributor臓器ネットワークの老化とフレイル・ロコモ)日本医学会連合 2024/08 9784784923854
  • 公認心理師カリキュラム準拠 人体の構造と機能及び疾病 第2版
    堀田晴美; 渡辺信博 (Contributor5章 加齢と疾患)医歯薬出版株式会社 2024/01 9784263266724
  • 自律神経 初めて学ぶ方のためのマニュアル
    渡辺信博; 堀田晴美 (Contributor脳循環の調節機構)中外医学社 2022/04 9784498328808
  • 堀田晴美; 渡辺信博 (Joint work心地よさを伝える神経線維)医歯薬出版 2014/09 9784263240649 viii, 313p
  • 老化ゲノム300
    渡辺信博; 内田さえ; 堀田晴美 (CALCB)丸山直記，石神昭人，大澤郁郎，豊田雅士，佐藤裕子編・東京都健康長寿医療センター研究所 2013

Works

  • 海外文献紹介 One-year aerobic exercise increases cerebral blood flow in cognitively normal older adults. (1年間の有酸素運動は認知機能が正常な高齢者の脳血流を増加させる)
    渡辺信博 Web service 2023/01
  • 海外文献紹介 Hyperexcitable arousal circuits drive sleep instability during aging. (過興奮性の覚醒回路が加齢に伴う睡眠を不安定にさせる)
    渡辺信博 Web service 2022/05
  • 海外文献紹介 Decreased pH in the aging brain and Alzheimer's disease.
    渡辺信博 Web service 2021/09
  • 海外文献紹介 Loss of cholinergic innervation differentially affects eNOS-mediated blood flow, drainage of Aβ and cerebral amyloid angiopathy in the cortex and hippocampus of adult mice
    渡辺信博 Web service 2021/01
  • 海外文献紹介 Brain control of humoral immune responses amenable to behavioural modulation.
    渡辺信博 Web service 2020/05
  • 海外文献紹介 Amyloid β oligomers constrict human capillaries in Alzheimer's disease via signaling to pericytes.
    渡辺信博 Web service 2019/09
  • 海外文献紹介 Functional aspects of meningeal lymphatics in ageing and Alzheimer’s disease.
    渡辺信博 Web service 2019/01
  • 海外文献紹介 Dietary salt promotes neurovascular and cognitive dysfunction through a gut-initiated TH17 response.
    渡辺信博 Web service 2018/05
  • 海外文献紹介 Inflammasome-driven catecholamine catabolism in macrophases blunts lipolysis during ageing.
    渡辺信博 Web service 2017/11
  • 海外文献紹介 Hypofunctional TrkA accounts for the absence of pain sensitization in the African naked mole-rat.
    渡辺信博 Web service 2017/05
  • 海外文献紹介 Gut microbiota depletion from early adolescence in mice: Implications for brain and behaviour.
    渡辺信博 Web service 2016/11
  • 海外文献紹介 TRPV1 pain receptors regulate longevity and metabolism by neuropeptide signaling.
    渡辺信博 Web service 2016/05
  • 海外文献紹介 Sleep drives metabolite clearance from the adult brain.
    渡辺信博 Web service 2015/11
  • 海外文献紹介 Capillary pericytes regulate cerebral blood flow in health and disease. 基礎老化研究・38巻・3号, pp. 69-70.
    渡辺信博 Others 2014/09

MISC

Awards & Honors

  • 2024/03 日本生理学会 2023年度 第14回 日本生理学会 入澤宏・彩記念JPS優秀論文賞（入澤賞）
     
    受賞者: 渡辺信博、奈良毬那、鈴木志穂子、杉江正光、山本高穂、堀田晴美
  • 2021/06 Japan Society for Biomedical Gerontology Most Impressive Presentator at the 44th annual meeting of Japan Society for Biomedical Gerontology
     
    受賞者: 渡辺 信博
  • 2017/10 IDO-NO-NIPPON-SHA,Inc 41st Shirota award
  • 2015/06 29th Japan Geriatric Society meeting Poster presentation award in conjunct poster session
  • 2014/03 91st Japan Physiological Society meeting Poster award
  • 2008/07 Royal Melbourne Institute of Technology (Australia) Best student poster award
  • 2007/01 Australian Neuroscience Society Student Travel Award
  • 2006/01 Australian Neuroscience Society Student Travel Award
  • 2005/06 Australian Spinal Research Foundation Best poster presentation award
  • 2004/02 Royal Melbourne Institute of Technology (Australia) Royal Melbourne Institute of Technology International Scholarship

Research Grants & Projects

  • Japan Society for the Promotion of Science：Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C)
    Date (from‐to) : 2021/04 -2025/03 
    Author : 渡邉 信博
     
    睡眠を司るホルモンであるメラトニンは脳（松果体）で合成・分泌されるホルモンで、自律神経（交感神経）の活動により分泌調節される。臨床的には、皮膚をさする刺激が入眠を促し、睡眠の質を高めることが報告されているが、皮膚への刺激がメラトニン分泌に影響を及ぼすことを実証した報告は見当たらない。そこで本研究では、皮膚への刺激が松果体からのメラトニン分泌に及ぼす影響とその神経性機序を明らかにすることを目的とする。 今年度は、マイクロダイアリシス法によりラットの松果体の潅流液を回収し、液中に含まれるメラトニン量をELISA法により定量化する方法を確立した。 麻酔下の雄性ラットの頭蓋骨の一部を除去して上矢状静脈を切除し、松果体を視認しながら透析膜のついたマイクロダイアリシスプローブを刺入した。灌流液を毎分1μLの速度で流し、氷上に置いたサンプルカップ中に灌流液を回収した。 その結果、回収した灌流液中に含まれるメラトニン濃度は数10 pg/mL程度であること、β受容体刺激薬を全身投与することにより灌流液中のメラトニン濃度が著しく増加することが分かった。 さらに、灌流液を20分毎に繰り返し採取し灌流液中のメラトニン濃度の経時変化を検討した。その結果、灌流液中のメラトニン濃度は安定しており、サンプル間の違いは約10%程度であることが分かった。
  • Japan Society for the Promotion of Science：Grants-in-Aid for Scientific Research
    Date (from‐to) : 2016/10 -2020/03 
    Author : Watanabe Nobuhiro
     
    Musculoskeletal disorders such as neck-shoulder stiffness and low back pain are one of chronic symptoms that many people suffer from. It has been reported that patients with chronic pain may also have cardiovascular dysfunctions such as orthostatic hypotension. The present study aimed to elucidate plastic change of cardiovascular response to skeletal muscle pain and its neural mechanisms, particularly focusing on inflammation which is related to pain chronicity. Experiments were performed on anesthetized rats. To induce inflammation in skeletal muscles, carrageenan solution was intramuscularly injected a day before experiment. Pressure stimulation applied to rat's calf altered heart rate and blood pressure. When pressure stimulation was applied to an inflamed calf, increases in heart rate and blood pressure were exaggerated. Additionally, the contribution of cardiac sympathetic efferent nerves to such cardiovascular responses was suggested.
  • Japan Society for the Promotion of Science：Grants-in-Aid for Scientific Research Grant-in-Aid for Young Scientists (B)
    Date (from‐to) : 2013/04 -2017/03 
    Author : Watanabe Nobuhiro
     
    Mechanical pressure stimulation applied to the calf alters heart rate in anesthetized animals. The aim of the present study was to establish an assessment method for muscle pain in anesthetized animals by using cardiac function changes in response to muscle stimulation. Heart rate, arterial pressure and cardiac sympathetic nerve activity were recorded during experiments. Heart rate changes (increase and decrease) in response to pressure stimulation of the calf muscles were almost abolished by blocking cardiac sympathetic nerve activity. Additionally, experiments that cardiac sympathetic nerve activity were recorded revealed that nerve activity changes occurred in parallel with heart rate changes. In the calf inflamed by inflammatory substance administration, pressure stimulation-induced increases in cardiac sympathetic nerve activity and heart rate exaggerated.
  • 骨格筋の痛みが及ぼす循環機能への影響
    東京都健康長寿医療センター：東京都健康長寿医療センター理事長研究奨励費
    Date (from‐to) : 2014/05 -2015/03 
    Author : 渡辺信博
  • Japan Society for the Promotion of Science：Grants-in-Aid for Scientific Research Grant-in-Aid for Young Scientists (B)
    Date (from‐to) : 2011 -2012 
    Author : WATANABE Nobuhiro
     
    The present study examined the effect of gentle cutaneous stimulation (touch) and its mechanism using heart rate responses to noxious heat stimulation as an indicator in anesthetized rats. We found that touch using a soft elastomer brush inhibited heat-induced heart rate responses. Additionally, the inhibitory effect of touch on heart rate responses was abolished by blocking spinal μ-opioid receptors.

Media Coverage

  • 新たなイメージング技術で見る脳血管のはたらき
    Date : 2023/07/04
    Publisher, broadcasting station: 東京都健康長寿医療センター研究所
    https://www.tmghig.jp/research/topics/202307-15022/ Internet
  • 慢性痛を改善！？「不思議な鍼（はり）」の効果に迫る
    Date : 2022/01/10
    Publisher, broadcasting station: NHK
    Program, newspaper magazine: 東洋医学ホントのチカラ「健康の大問題 解決SP」
    https://www.nhk.or.jp/kenko/atc_1365.html Media report
  • 皮膚刺激の鎮痛法・モルヒネに似た物質分泌
    Date : 2010/06/28
    Writer: Myself
    Program, newspaper magazine: 日経産業新聞
    Paper
  • 軽い皮膚刺激による鎮痛法の探索 ～自律神経反応を指標として～
    Date : 2010
    Publisher, broadcasting station: 東京都健康長寿医療センター研究所（東京都老人総合研究所）
    Program, newspaper magazine: 老人研NEWS
    Pr

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