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Akasaka Keiko

    Molecular Glycobiology　Researcher
Last Updated :2024/12/27

Researcher Information

Research funding number

  • 70415496

J-Global ID

Research Areas

  • Life sciences / Applied biochemistry
  • Life sciences / Functional biochemistry

Published Papers

Books etc

  • Vitamins and Hormones
    K. Akasaka-Manya; H. Manya; T. Endo (ContributorFunction and Change with Aging of α-Klotho in the Kidney)Elsevier 2016

MISC

Awards & Honors

  • 2018 JB Award
     Excess APP O-glycosylation by GalNAc-T6 decreases Aβ production 
    受賞者: Keiko Akasaka-Manya
  • 2011 日本生化学会 Samuro Kakiuchi Memorial Research Award for Young Scientists (by Gushinkai)
     糖転移酵素によるAPP代謝調節機構の解析 
    受賞者: Keiko Akasaka-Manya

Research Grants & Projects

  • Japan Society for the Promotion of Science：Grants-in-Aid for Scientific Research
    Date (from‐to) : 2019/04 -2022/03 
    Author : MANYA KEIKO
     
    Our previous studies have shown that the expression of glycosyltransferases changes with the onset and progression of Alzheimer's disease (AD), and that changes in O-glycosylation on amyloid precursor protein (APP) affect APP metabolism and alter amyloid-β (Aβ) production. In this study, to elucidate the mechanism, we analyzed the subcellular localization of APP with altered O-glycosylation by overexpression of glycosyltransferases that most affected Aβ production. We found that partial O-glycosylation did not alter the subcellular localization of APP.
  • Japan Society for the Promotion of Science：Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (B)
    Date (from‐to) : 2013/04 -2016/03 
    Author : Endo Tamao; Masami Miura; Miura Yuri; Keiko Manya
     
    α-Dystroglycanopathy is a type of congenital muscular dystrophies with neurological abnormality. Defect of O-mannosyl glycan on α-dystroglycan is a primary cause of α-dystroglycanopathy. In this study, we elucidated the precise structure of O-mannosyl glycan that contains ribitol 5-phosphate (Rbo5P); [GlcA-Xyl]n-Rbo5P-1Rbo5P-3GalNAcβ1-3GlcNAcβ1-4(phospho-6)Man. Rbo5P forms a tandem repeat and functions as a scaffold for the formation of the ligand-binding moiety. We also revealed that three α-dystroglycanopathy-causing proteins with unknown function, fukutin (Fukuyama Congenital Muscular Dystrophy), FKRP (Limb Girdle Muscular Dystrophy) and ISPD (Walker-Warburg syndrome), are involved in the synthesis of tandem Rbo5P. Fukutin and FKRP are Rbo5P transferases and ISPD synthesizes CDP-Rbo. We reported a novel O-mannosyl glycan structure and provided new insight into the molecular basis of its biosynthetic pathway and its role in nerve function in the brain.
  • 糖転移酵素によるAPP代謝調節機構の解析
    文部科学省: 科学研究費補助金(若手研究(B))
    Date (from‐to) : 2010 -2011 
    Author : 赤阪(萬谷)啓子
  • 筋ジストロフィー症の発症に関わる糖鎖合成酵素の機能解析とその破綻
    文部科学省: 科学研究費補助金(若手研究(B))
    Date (from‐to) : 2007 -2009 
    Author : 赤阪(萬谷)啓子

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