Japan Society for the Promotion of Science:Grants-in-Aid for Scientific Research Grant-in-Aid for Early-Career Scientists
Date (from‐to) : 2020/04 -2022/03
Author : Tago Tetsuro
Histone deacetylase 6 (HDAC6) is an enzyme with unique properties, such as cytoplasmic localization and ubiquitin binding. HDAC6 has emerged as an interesting therapeutic target in the treatment of neurodegenerative disorders exhibiting abnormal protein aggregation in the brain. In vivo imaging of HDAC6 by positron emission tomography (PET) should help the research and diagnosis of the disorders.
In this study, we radiosynthesized and evaluated an 18F-labeled tetrahydroquinoline derivative as a PET probe for HDAC6 imaging. The 18F-labeled probe was synthesized using an automated radiosynthesizer. Preclinical studies demonstrated that this probe had a high HDAC6 selectivity and good brain permeability in mice. Further studies are warranted to clarify the clinical utility of the probe.